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The intravenous dose causing 50% of opioid-naive experimental subjects to die (LD 50) is "3 mg/kg in rats, 1 mg/kg in cats, 14 mg/kg in dogs, and 0.03 mg/kg in monkeys." [ 96 ] The LD 50 in mice has been given as 6.9 mg/kg by intravenous administration, 17.5 mg/kg intraperitoneally, 27.8 mg/kg by oral administration. [ 97 ]
CBS Broadcasting Inc., commonly shortened to CBS (an abbreviation of its original name, Columbia Broadcasting System), is an American commercial broadcast television and radio network serving as the flagship property of the CBS Entertainment Group division of Paramount Global and is one of the company's three flagship subsidiaries, along with namesake Paramount Pictures and MTV.
Pennsylvania (/ ˌ p ɛ n s ɪ l ˈ v eɪ n i ə / ⓘ PEN-sil-VAY-nee-ə, lit. ' Penn's forest country '), officially the Commonwealth of Pennsylvania [b] (Pennsylvania Dutch: Pennsylvanie), [7] is a state spanning the Mid-Atlantic, Northeastern, Appalachian, and Great Lakes regions of the United States.
In 1969, the Government of India announced the introduction of a new express train capable of reaching speeds of up to 120 km/h (75 mph) in the railway budget and the first Rajdhani Express was flagged off from New Delhi to Howrah in March 1969. [28] [29] In 1974, Indian Railways endured a 20-day strike.
The 50% top rate of income tax was reduced to 45% by the Conservative–Liberal Democrat coalition. [177] Alongside a reduction in tax and commitments to keep taxation low, the Conservative Party has significantly reduced government spending, through the austerity programme which commenced in 2010, subsequent to the 2007–2008 financial crisis .
Costco membership card from Iceland. Costco's earliest predecessor, Price Club, opened its first store on July 12, 1976, on Morena Boulevard in San Diego, California.It was founded three months earlier by Sol Price and his son, Robert, following a dispute with the new owners of FedMart, Price's previous membership-only discount store. [14]
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